Article
Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukaemia.
International journal of immunogenetics - 1 Feb 2006
Bogunia-Kubik K, Mazur G, Urbanowicz I, Wróbel T, Kuliczkowski K, Woźniak M, Lange A
Abstract excerpt
B-cell chronic lymphocytic leukaemia (B-CLL) is a lymphoproliferative disorder characterized by clonal expansion of B lymphocytes. The present study aimed to determine whether there is an association between the polymorphic features located within the promoter/enhancer region of tumour necrosis factor-alpha (TNFA) gene and susceptibility to B-CLL. TNFA (-308 G/A) promoter single nucleotide polymorphism (SNP) was...
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