Article
No association of the NFKB1 insertion/deletion promoter polymorphism with survival in colorectal and renal cell carcinoma as well as disease progression in B-cell chronic lymphocytic leukemia.
Pharmacogenetics and genomics - 1 Nov 2006
Riemann Kathrin, Becker Lucie, Struwe Henrike, Nückel Holger, Dührsen Ulrich, Alakus Hakan, Winde Günter, Neuhäuser Markus, Rübben Herbert, Schmitz Klaus J, Wohlschlaeger Jeremias, Schmid Kurt W, Siffert Winfried
Abstract excerpt
PURPOSE: Nuclear factor-kappaB (NF-kappaB) is an inducible transcription factor that plays a major role in the regulation of genes involved in immune and inflammatory response. Activation of NF-kappaB has also been associated with apoptosis and proliferation, thereby potentially also controlling oncogenesis. A functional insertion/deletion polymorphism has been identified in the promoter region of NFKB1, which...
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