Article
A functional promotor polymorphism of TNF-alpha is associated with primary gastric B-Cell lymphoma.
The American journal of gastroenterology - 1 Dec 2005
Hellmig Stephan, Fischbach Wolfgang, Goebeler-Kolve Maria-Elisabeth, Fölsch Ulrich Robert, Hampe Jochen, Schreiber Stefan
Abstract excerpt
BACKGROUND AND AIMS: The host genetic background to develop primary gastric B-cell lymphoma in patients with chronic Helicobacter pylori infection is unknown. Tumor necrosis factor (TNF)-alpha plays a key role in H. pylori-associated inflammation and appears to be involved in the evolution of lymphoproliferative disorders. We investigated four functional promotor polymorphisms in the TNF-alpha gene for...
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