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Article

Distribution of human SNPs and its effect on high-throughput genotyping.

Human mutation - 1 Mar 2006

Koboldt Daniel C, Miller Raymond D, Kwok Pui-Yan

Abstract excerpt

Utilizing the results of extensive single nucleotide polymorphism (SNP) studies in humans, stimulated by the International HapMap Project, we present evidence that SNPs are not randomly spaced across the genome, but are somewhat clustered. This observation has important consequences for assay design, since hidden variants in primer sites can affect the accuracy of data. Indeed, using data from the calibration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16425292
DOI: 10.1002/humu.20286
PMCID: PMC1861817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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