Article
The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns.
Pharmacogenetics and genomics - 1 Feb 2006
Nukui Tomoko, Day Richard D, Gordish-Dressman Heather A, Harger Gail, Bigbee William L, Ness Roberta B, Romkes Marjorie
Abstract excerpt
Prenatal exposure to carcinogens results in newborn DNA damage which in turn is associated with impaired health conditions in both childhood and adulthood. The present study aimed to evaluate whether phase I and II biotransformation enzyme genetic polymorphisms in combination with environmental exposures during pregnancy result in elevated levels of newborn DNA damage. Maternal peripheral and umbilical cord blood...
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