Article
Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns.
Carcinogenesis - 1 Nov 2016
Iyer Shoba, Wang Ya, Xiong Wei, Tang Deliang, Jedrychowski Wieslaw, Chanock Stephen, Wang Shuang, Stigter Laura, Mróz Elzbieta, Perera Frederica
Abstract excerpt
Polycyclic aromatic hydrocarbons (PAH) are a class of chemicals common in the environment. Certain PAH are carcinogenic, although the degree to which genetic variation influences susceptibility to carcinogenic PAH remains unclear. Also unknown is the influence of genetic variation on the procarcinogenic effect of in utero exposures to PAH. Benzo[ a ]pyrene (B[ a ]P) is a well-studied PAH that is classified as a...
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