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Article

A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.

Molecular biology of the cell - 1 Mar 1994

Brill J A, Elion E A, Fink G R

Abstract excerpt

We have isolated dominant gain-of-function (gf) mutations in FUS3, a Saccharomyces cerevisiae mitogen-activated protein (MAP) kinase homolog, that constitutively activate the yeast mating signal transduction pathway and confer hypersensitivity to mating pheromone. Surprisingly, the phenotypes of dominant FUS3gf mutations require the two protein kinases, STE7 and STE11. FUS3gf kinases are hyperphosphorylated in...

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Identifiers

PMID: 8049522
DOI: 10.1091/mbc.5.3.297
PMCID: PMC301038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog.PMID 8049522Read ↗

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The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5.Semantic proximity Read ↗

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Modulators of MAPK pathway activity during filamentous growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7.Semantic proximity Read ↗

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.Semantic proximity Read ↗

Functional redundancy in the yeast cell cycle: FUS3 and KSS1 have both overlapping and unique functions.Semantic proximity Read ↗

A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission.Semantic proximity Read ↗

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast.Semantic proximity Read ↗

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