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Article

Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.

Cancer research - 15 Jan 2006

Maggio-Price Lillian, Treuting Piper, Zeng Weiping, Tsang Mark, Bielefeldt-Ohmann Helle, Iritani Brian M

Abstract excerpt

Accumulating evidence suggests that intestinal microbial organisms may play an important role in triggering and sustaining inflammation in individuals afflicted with inflammatory bowel disease (IBD). Moreover, individuals with IBD are at increased risk for developing colorectal cancer, suggesting that chronic inflammation may initiate genetic or epigenetic changes associated with cancer development. We tested the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16424015
DOI: 10.1158/0008-5472.CAN-05-2448
PMCID: PMC5367923

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.PMID 16424015Read ↗

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