Article
Methionine catabolism in Saccharomyces cerevisiae.
FEMS yeast research - 1 Jan 2006
Perpète Philippe, Duthoit Olivier, De Maeyer Simon, Imray Louise, Lawton Andrew I, Stavropoulos Konstantinos E, Gitonga Virginia W, Hewlins Michael J E, Dickinson J Richard
Abstract excerpt
The catabolism of methionine to methionol and methanethiol in Saccharomyces cerevisiae was studied using (13)C NMR spectroscopy, GC-MS, enzyme assays and a number of mutants. Methionine is first transaminated to alpha-keto-gamma-(methylthio)butyrate. Methionol is formed by a decarboxylation reaction, which yields methional, followed by reduction. The decarboxylation is effected specifically by Ydr380wp....
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