Article
The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders.
Genome biology - 1 Jan 2005
Law G Lynn, Bickel Kellie S, MacKay Vivian L, Morris David R
Abstract excerpt
BACKGROUND: Translational efficiencies in Saccharomyces cerevisiae vary from transcript to transcript by approximately two orders of magnitude. Many of the poorly translated transcripts were found to respond to the appropriate external stimulus by recruiting ribosomes. Unexpectedly, a high frequency of these transcripts showed the appearance of altered 5' leaders that coincide with increased ribosome loading....
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