Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006

Matsuki Masahiro, Kunitomo Hirofumi, Iino Yuichi

Abstract excerpt

The heterotrimeric G protein G(o) is abundantly expressed in the mammalian nervous system and modulates neural activities in response to various ligands. However, G(o)'s functions in living animals are less well understood. Here, we demonstrate that GOA-1 G(o)alpha has a fundamental role in olfactory adaptation in Caenorhabditis elegans. Impairment of GOA-1 G(o)alpha function and excessive activation of EGL-30...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Physiological Phenomena
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diacylglycerol Kinase

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Nervous System

Share to Odorants

Source

Open in PubMed Open full text

Identifiers

PMID: 16418272
DOI: 10.1073/pnas.0506954103
PMCID: PMC1347976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.PMID 16418272Read ↗

The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans.Semantic proximity Read ↗

Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity.Semantic proximity Read ↗

G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.Semantic proximity Read ↗

Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.Semantic proximity Read ↗

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.Semantic proximity Read ↗

Impaired olfactory behavior in mice deficient in the alpha subunit of G(o).Semantic proximity Read ↗

The complete family of genes encoding G proteins of Caenorhabditis elegans.Semantic proximity Read ↗

Participation of the protein Go in multiple aspects of behavior in C. elegans.Semantic proximity Read ↗

Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans.Semantic proximity Read ↗

C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.Semantic proximity Read ↗

EGL-4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals.Semantic proximity Read ↗

Caenorhabditis elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.