Article
The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans.
Neuron - 19 Dec 2002
L'Etoile Noelle D, Coburn Cara M, Eastham Jeffery, Kistler Amy, Gallegos Gloriana, Bargmann Cornelia I
Abstract excerpt
Prolonged odor exposure causes a specific, reversible adaptation of olfactory responses. A genetic screen for negative regulators of olfaction uncovered mutations in the cGMP-dependent protein kinase EGL-4 that disrupt olfactory adaptation in C. elegans. G protein-coupled olfactory receptors within the AWC olfactory neuron signal through cGMP and a cGMP-gated channel. The cGMP-dependent kinase functions in AWC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.