Article
EGL-4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2021
Hino Takahiro, Hirai Shota, Ishihara Takeshi, Fujiwara Manabi
Abstract excerpt
Interneurons, innervated by multiple sensory neurons, need to integrate information from these sensory neurons and respond to sensory stimuli adequately. Mechanisms how sensory information is integrated to form responses of interneurons are not fully understood. In Caenorhabditis elegans, loss-of-function mutations of egl-4, which encodes a cGMP-dependent protein kinase (PKG), cause a defect in chemotaxis to...
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