Article
Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.
Circulation - 24 Jan 2006
Bezzina Connie R, Shimizu Wataru, Yang Ping, Koopmann Tamara T, Tanck Michael W T, Miyamoto Yoshihiro, Kamakura Shiro, Roden Dan M, Wilde Arthur A M
Abstract excerpt
BACKGROUND: Reduced cardiac sodium current slows conduction and renders the heart susceptible to ventricular fibrillation. Loss of function mutations in SCN5A, encoding the cardiac sodium channel, are one cause of the Brugada syndrome, associated with slow conduction and a high incidence of ventricular fibrillation, especially in Asians. In this study, we tested the hypothesis that an SCN5A promoter polymorphism...
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