Article
From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.
Trends in cardiovascular medicine - 1 Apr 2014
van den Boogaard Malou, Barnett Phil, Christoffels Vincent M
Abstract excerpt
The electrical activity of the heart depends on the correct interplay between key transcription factors and cis-regulatory elements, which together regulate the proper heterogeneous expression of genes encoding for ion channels and other proteins. Genome-wide association studies of ECG parameters implicated genetic variants in the genes for these factors and ion channels modulating conduction and depolarization....
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