Article
Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes.
Journal of the American Heart Association - 13 Sept 2016
Yagihara Nobue, Watanabe Hiroshi, Barnett Phil, Duboscq-Bidot Laetitia, Thomas Atack C, Yang Ping, Ohno Seiko, Hasegawa Kanae, Kuwano Ryozo, Chatel Stéphanie, Redon Richard, Schott Jean-Jacques, Probst Vincent, Koopmann Tamara T, Bezzina Connie R, Wilde Arthur A M, Nakano Yukiko, Aiba Takeshi, Miyamoto Yoshihiro, Kamakura Shiro, Darbar Dawood, Donahue Brian S, Shigemizu Daichi, Tanaka Toshihiro, Tsunoda Tatsuhiko, Suda Masayoshi, Sato Akinori, Minamino Tohru, Endo Naoto, Shimizu Wataru, Horie Minoru, Roden Dan M, Makita Naomasa
Abstract excerpt
BACKGROUND: Mutations in the coding sequence of SCN5A, which encodes the cardiac Na(+) channel α subunit, have been associated with inherited susceptibility to various arrhythmias. Variable expression of SCN5A is a possible mechanism responsible for this pleiotropic effect; however, it is unknown whether variants in the promoter and regulatory regions of SCN5A also modulate the risk of arrhythmias. METHODS AND...
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