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Article

A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.

Nature cell biology - 1 Dec 2003

Wang Dan, King Shelby M, Quill Timothy A, Doolittle Lynda K, Garbers David L

Abstract excerpt

It has long been speculated that intracellular pH is a critical regulator of both invertebrate and vertebrate sperm motility, and sodium-hydrogen exchange has been suggested as a mediator of such pH(i) regulation in various instances. Two sodium-hydrogen exchangers (NHE1 and NHE5) are expressed in spermatozoa. However, elimination of the NHE1 gene fails to cause infertility, suggesting that normal sperm function...

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Identifiers

PMID: 14634667
DOI: 10.1038/ncb1072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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