Article
CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese.
Clinica chimica acta; international journal of clinical chemistry - 1 May 2006
Chern Herng-Der, Ueng Tzuu-Huei, Fu Yi-Ping, Cheng Chun-Wen
Abstract excerpt
BACKGROUND: Warfarin prevents thromboembolism in patients with prosthetic heart valvular replacement. Cytochrome P4502C9 (CYP2C9) is polymorphic in human and is principally responsible for the metabolism of warfarin. However, known CYP2C9 polymorphisms cannot entirely account for the low dose requirement of warfarin in Chinese-Taiwanese receiving mitral valve replacement. We screened a new polymorphism of CYP2C9...
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