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Article

Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting.

Bioinformatics (Oxford, England) - 15 Mar 2006

Thomas Alun, Camp Nicola J

Abstract excerpt

SUMMARY: Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated. AVAILABILITY: The Java classes and Javadocs pages for \mathsf\hbox GeneCountAlleles can be obtained from...

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PMID: 16410318
DOI: 10.1093/bioinformatics/btk049

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