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Article

Hypoxia promotes nucleus pulposus phenotype in 3D scaffolds in vitro and in vivo: laboratory investigation.

Journal of neurosurgery. Spine - 1 Aug 2014

Feng Ganjun, Li Li, Hong Ying, Liu Hao, Song Yueming, Pei Fuxing, Ma Peter X, Gong Quan, Gupte Melanie J

Abstract excerpt

OBJECT: The role of oxygen in disc metabolism remains a matter of debate. Whether the effect of hypoxic priming on the nucleus pulposus phenotype can be maintained in vivo is not clear. The goal of the present study was to test the hypothesis that priming in a low oxygen tension in vitro could promote a nucleus pulposus phenotype in vivo. METHODS: Bovine nucleus pulposus cells were seeded in 3D scaffolds and...

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Identifiers

PMID: 24855996
DOI: 10.3171/2014.4.SPINE13870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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