Article
Genome-wide linkage screen for testicular germ cell tumour susceptibility loci.
Human molecular genetics - 1 Feb 2006
Crockford Gillian P, Linger Rachel, Hockley Sarah, Dudakia Darshna, Johnson Lola, Huddart Robert, Tucker Kathy, Friedlander Michael, Phillips Kelly-Anne, Hogg David, Jewett Michael A S, Lohynska Radka, Daugaard Gedske, Richard Stéphane, Chompret Agnes, Bonaïti-Pellié Catherine, Heidenreich Axel, Albers Peter, Olah Edith, Geczi Lajos, Bodrogi Istvan, Ormiston Wilma J, Daly Peter A, Guilford Parry, Fosså Sophie D, Heimdal Ketil, Tjulandin Sergei A, Liubchenko Ludmila, Stoll Hans, Weber Walter, Forman David, Oliver Timothy, Einhorn Lawrence, McMaster Mary, Kramer Joan, Greene Mark H, Weber Barbara L, Nathanson Katherine L, Cortessis Victoria, Easton Douglas F, Bishop D Timothy, Stratton Michael R, Rapley Elizabeth A
Abstract excerpt
A family history of disease is a strong risk factor for testicular germ cell tumour (TGCT). In order to identify the location of putative TGCT susceptibility gene(s) we conducted a linkage search in 237 pedigrees with two or more cases of TGCT. One hundred and seventy-nine pedigrees were evaluated genome-wide with an average inter-marker distance of 10 cM. An additional 58 pedigrees were used to more intensively...
Topics
- Chromosome Mapping
- Chromosomes, Human, X
- Female
- Genetic Heterogeneity
- Genetic Linkage
- Genetic Predisposition to Disease