Article
Associations between cigarette smoking and mitochondrial DNA abnormalities in buccal cells.
Carcinogenesis - 1 Jun 2008
Tan Duanjun, Goerlitz David S, Dumitrescu Ramona G, Han Dingfen, Seillier-Moiseiwitsch Françoise, Spernak Stephanie M, Orden Roy Anthony, Chen Jinguo, Goldman Radoslav, Shields Peter G
Abstract excerpt
DNA alterations in mitochondria are believed to play a role in carcinogenesis and are found in smoking-related cancers. We sought to replicate earlier findings for the association of smoking with increased mitochondrial DNA (mtDNA) content in buccal cells and further hypothesized that there would be an increased number of somatic mtDNA mutations in smokers. Buccal cells and blood lymphocytes were studied from 42...
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