Article
Distinct prevalence of the CYP19 Delta3(TTTA)(7) allele in premenopausal versus postmenopausal breast cancer patients, but not in control individuals.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2002
Suspitsin E N, Grigoriev M Y, Togo A V, Kuligina E S, Belogubova E V, Pozharisski K M, Chagunava O L, Sokolov E P, Theillet C, Berstein L M, Hanson K P, Imyanitov E N
Abstract excerpt
The CYP19 gene encodes the enzyme aromatase, which plays a key role in the conversion of androgens to oestrogens. A polymorphism in CYP19 in intron 4 (TTTA)n has been reported to be associated with breast cancer (BC) risk, although conflicting evidence has also been published. Here, we employ a non-traditional, highly demonstrative design of a molecular epidemiological study, where the comparison of BC cases and...
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