Fusion partner-specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML.

doi:10.1182/bloodadvances.2020002457

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Article

Fusion partner-specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML.

Blood advances - 13 Oct 2020

Matsuo Hidemasa, Yoshida Kenichi, Nakatani Kana, Harata Yutarou, Higashitani Moe, Ito Yuri, Kamikubo Yasuhiko, Shiozawa Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Okada Ai, Nannya Yasuhito, Takeda June, Ueno Hiroo, Kiyokawa Nobutaka, Tomizawa Daisuke, Taga Takashi, Tawa Akio, Miyano Satoru, Meggendorfer Manja, Haferlach Claudia, Ogawa Seishi, Adachi Souichi

Abstract excerpt

Mixed-lineage leukemia (MLL) gene rearrangements are among the most frequent chromosomal abnormalities in acute myeloid leukemia (AML). MLL fusion patterns are associated with the patient's prognosis; however, their relationship with driver mutations is unclear. We conducted sequence analyses of 338 genes in pediatric patients with MLL-rearranged (MLL-r) AML (n = 56; JPLSG AML-05 study) alongside data from the...

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PMID: 32991719
DOI: 10.1182/bloodadvances.2020002457
PMCID: PMC7556160

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