Article
Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia.
Archives of medical research - 1 Nov 2016
Kaur Maneet, de Smith Adam J, Selvin Steve, Zhang Luoping, Cunningham Marc, Kang Michelle W, Hansen Helen M, Cooper Robert M, McKean-Cowdin Roberta, Wiemels Joseph L, Metayer Catherine
Abstract excerpt
BACKGROUND AND AIMS: Childhood acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease, and mutations in the KRAS and NRAS oncogenes are present at diagnosis in about one-fifth of cases. Ras mutations were previously associated with environmental exposures in leukemias as well as in many other cancer types. This study examined whether Ras mutation could define a unique etiologic group of...
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