Article
Evidence of an association between desmoglein 3 haplotypes and pemphigus vulgaris.
The British journal of dermatology - 1 Jan 2006
Capon F, Bharkhada J, Cochrane N E, Mortimer N J, Setterfield J F, Reynaert S, Black M M, Vaughan R W, Trembath R C, Harman K E
Abstract excerpt
BACKGROUND: Pemphigus vulgaris (PV, OMIM 169610) is a severe blistering disorder of the skin and mucous membranes, caused by the production of autoantibodies directed against the epithelial adhesive protein desmoglein 3. Although an association between PV and HLA class II alleles has been established, the genetic factors predisposing to the disease remain poorly understood, the rarity of PV hampering the...
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