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Article

IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.

Experimental dermatology - 1 Jan 2008

Müller Ralf, Svoboda Vera, Wenzel Elke, Müller Hans-Helge, Hertl Michael

Abstract excerpt

Pemphigus vulgaris (PV) is associated with autoantibodies against desmoglein (Dsg) 3 inducing epidermal loss of adhesion. The major pathogenic epitopes of Dsg3 are presumably dependent of their conformation. The aim of this study was to characterize the IgG reactivity of sera from a cohort of clinically well-characterized PV patients against presumably non-conformational subdomains of the Dsg3 ectodomain...

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Autoantibodies
Autoimmunity
Biomarkers
Epitopes
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Structure, Tertiary

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PMID: 18095943
DOI: 10.1111/j.1600-0625.2007.00615.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris.PMID 18095943Read ↗

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