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Article

The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells.

The Biochemical journal - 15 Apr 2006

Borghini Silvia, Bachetti Tiziana, Fava Monica, Di Duca Marco, Cargnin Francesca, Fornasari Diego, Ravazzolo Roberto, Ceccherini Isabella

Abstract excerpt

The TLX2 (HOX11L1, Ncx, Enx) and PHOX2B genes encode transcription factors crucial in the development of neural-crest-derived cells, leading to ANS (autonomic nervous system) specific neuronal lineages. Moreover, they share a similar expression pattern and are both involved in downstream steps of BMP (bone morphogenetic protein) signalling. In an attempt to reconstruct the gene network sustaining the correct...

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Identifiers

PMID: 16402914
DOI: 10.1042/BJ20051386
PMCID: PMC1422762

Genes

TLX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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