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Article

Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis.

BMC neurology - 2 Jun 2011

Samaan Zainab, Gaysina Daria, Cohen-Woods Sarah, Craddock Nick, Jones Lisa, Korszun Ania, Owen Mike, Mente Andrew, McGuffin Peter, Farmer Anne

Abstract excerpt

BACKGROUND: Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis...

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Source

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Identifiers

PMID: 21635773
DOI: 10.1186/1471-2377-11-66
PMCID: PMC3120667

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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