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Article

Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi.

Nucleic acids research - 1 Jan 2005

Kuhlmann Markus, Borisova Branimira E, Kaller Markus, Larsson Pontus, Stach Dirk, Na Jianbo, Eichinger Ludwig, Lyko Frank, Ambros Victor, Söderbom Fredrik, Hammann Christian, Nellen Wolfgang

Abstract excerpt

We have identified a DNA methyltransferase of the Dnmt2 family in Dictyostelium that was denominated DnmA. Expression of the dnmA gene is downregulated during the developmental cycle. Overall DNA methylation in Dictyostelium is approximately 0.2% of the cytosine residues, which indicates its restriction to a limited set of genomic loci. Bisulfite sequencing of specific sites revealed that DnmA is responsible for...

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PMID: 16282589
DOI: 10.1093/nar/gki952
PMCID: PMC1283529

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