Article
Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1).
International immunopharmacology - 1 Feb 2006
Katagiri Daichi, Hayashi Hidetoshi, Victoriano Ann Florence B, Okamoto Takashi, Onozaki Kikuo
Abstract excerpt
Gene expression from human immunodeficiency virus (HIV) provirus is a crucial step for the viral replication. Here we examined a potential role of 17beta-estradiol (E2) in HIV-1 transcription. Transient luciferase expression studies revealed that E2 activated HIV-LTR reporter gene in HEK293 cells when the cells were co-transfected with estrogen receptor alpha (ERalpha) but not ERbeta expression plasmid. This E2...
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