Article

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

2020-04-09

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks a curative therapy or vaccine. Despite the reduction in AIDS-related deaths achieved by current antiretroviral therapies, drawbacks including drug resistance and the failure to eradicate infection highlight the need to identify new pathways to target the infection. Circadian rhythms are endogenous 24-hour oscillations which regu...

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Literature Corpus work: 905d6f48-5ec2-5396-b00a-4b03a6a7a679
DOI: 10.1101/2020.04.09.031492

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