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Article

Estrogen Regulates KiSS1 Gene Expression through Estrogen Receptor α and SP Protein Complexes

27 Jul 2007

Abstract excerpt

Kisspeptins are natural ligands of G protein-coupled receptor-54. Activation of KiSS1/G protein-coupled receptor-54 signaling pathways results in potent activation of the hypothalamus-pituitary-gonadal axis and initiates puberty. Recent data have shown that in female mice, KiSS1 is positively regulated by estradiol (E(2)) in the anteroventral periventricular nucleus, an important reproductive neuroendocrine brain...

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Identifiers

PMID: 17656465
DOI: 10.1210/en.2007-0154

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