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Genetic analysis of glutathione S-transferase A1 polymorphism in the Chinese population and the influence of genotype on enzymatic properties.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Feb 2006

Ping Jie, Wang Hui, Huang Min, Liu Zhi-Su

Abstract excerpt

Genetic polymorphisms of human glutathione S-transferases (hGSTs) have important implications for drug efficacy and cancer susceptibility. hGSTA1 is the most abundant subfamily of hGSTs. The aim of this study was to investigate the distribution of hGSTA1 genetic polymorphism in the Chinese population and whether there exists the potential activity alterations caused by this polymorphism. Therefore, genomic DNA...

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PMID: 16280386
DOI: 10.1093/toxsci/kfj037

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