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Article

Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance.

Neurobiology of aging - 1 Feb 2006

Durga Jane, van Boxtel Martin P J, Schouten Evert G, Bots Michiel L, Kok Frans J, Verhoef Petra

Abstract excerpt

Low folate status has been associated with cognitive decline. We investigated the association of folate status and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism with performance on a battery of neuropsychological tests. Furthermore, we investigated whether the association of folate with cognitive performance was mediated by plasma homocysteine or risk of vascular disease. We used...

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Source

Identifiers

PMID: 16399216
DOI: 10.1016/j.neurobiolaging.2005.01.003

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance.PMID 16399216Read ↗

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