Article
Characterization of metformin transport system in NIH 3T3 cells.
Journal of cellular physiology - 1 Aug 1992
Khan N A, Wiernsperger N, Quemener V, Havouis R, Moulinoux J P
Abstract excerpt
The biochemical properties of the metformin transport system were studied in NIH 3T3 cells. 14C-metformin uptake appeared to be a sodium dependent process. Iso-osmotical replacement of Na+ by choline chloride in the assay medium resulted in a decrease of metformin uptake. Amiloride (200 microM) i...
Topics
- 3T3 Cells
- Amino Acids
- Animals
- Biological Transport
- Extracellular Space
- Ionophores
- Metformin
- Mice
- Mitoguazone
- Mutation
- Polyamines
- Sodium
- Spermidine
- Time Factors