Article
Characterisation of the promoter region of the human DNA-repair gene Rad51.
European journal of gynaecological oncology - 1 Jan 2005
Hasselbach L, Haase S, Fischer D, Kolberg H C, Stürzbecher H W
Abstract excerpt
PURPOSE OF INVESTIGATION: Regulatory elements of the 5'-flanking region of the DNA-repair gene Rad51 were analysed to characterise pathological alterations of Rad51 mRNA expression during tumour development. METHODS: Various fragments of the Rad51 promoter were cloned into the pGL3 reporter vector and the respective promoter activity was determined by luciferase assays in transfected U2-OS cells. Transcription...
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