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Article

The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.

Journal of cancer research and clinical oncology - 1 May 2015

Söderlund Leifler K, Asklid A, Fornander T, Stenmark Askmalm M

Abstract excerpt

PURPOSE: RAD51, a central player in the response to DNA damage, has been suspected to contribute to tumour resistance to therapy. A single-nucleotide polymorphism, RAD51 135G>C, in the untranslated region of the RAD51 gene elevates breast cancer risk among BRCA2 carriers. In this study, it was investigated whether this polymorphism is related to prognosis of breast cancer and RAD51 protein expression and whether...

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Source

Identifiers

PMID: 25354554
DOI: 10.1007/s00432-014-1859-0

Genes

RAD51
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.PMID 25354554Read ↗

RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies.Semantic proximity Read ↗

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.Semantic proximity Read ↗

RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects.Semantic proximity Read ↗

Association between the RAD51 135 G>C polymorphism and risk of cancer: a meta-analysis of 19,068 cases and 22,630 controls.Semantic proximity Read ↗

RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.Semantic proximity Read ↗

RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects.Semantic proximity Read ↗

Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.Semantic proximity Read ↗

Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls.Semantic proximity Read ↗

A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.Semantic proximity Read ↗

RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women.Semantic proximity Read ↗

Analysis of the G/C polymorphism in the 5'-untranslated region of the RAD51 gene in breast cancer.Semantic proximity Read ↗

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