Article
Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population.
International journal of clinical and experimental pathology - 1 Jan 2015
Mucha Bartosz, Kabzinski Jacek, Dziki Adam, Przybylowska-Sygut Karolina, Sygut Andrzej, Majsterek Ireneusz, Dziki Lukasz
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers in developed countries. Annually, over one million of new cases in the world are recorded. Majority of CRCs occur sporadically with dominant phenotype of chromosomal instability (CIN). Permanent exposure to DNA damaging agents such as ionizing radiation result in DNA double-stranded breaks, which create favorable conditions for chromosomal...
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