Article
Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach.
World journal of gastroenterology - 14 Jan 2022
Idris Abeer Babiker, Idris Alaa B, Gumaa Manal A, Idris Mohammed Babiker, Elgoraish Amanda, Mansour Mohamed, Allam Dalia, Arbab Bashir Mo, Beirag Nazar, Ibrahim El-Amin M, Hassan Mohamed A
Abstract excerpt
BACKGROUND: Helicobacter pylori (H. pylori) is a ubiquitous bacterium that affects nearly half of the world's population with a high morbidity and mortality rate. Polymorphisms within the tumor necrosis factor-alpha (TNF-A) promoter region are considered a possible genetic basis for this disease. AIM: To functionally characterize the genetic variations in the TNF-A 5'-region (-584 to +107) of Sudanese patients...
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