Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data.

doi:10.1046/j.1432-1033.2003.03671.x

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Article

Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data.

European journal of biochemistry - 1 Jul 2003

Duggleby Ronald G, Pang Siew Siew, Yu Hongqi, Guddat Luke W

Abstract excerpt

Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) catalyses the first step in branched-chain amino acid biosynthesis and is the target for sulfonylurea and imidazolinone herbicides, which act as potent and specific inhibitors. Mutants of the enzyme have been identified that are resistant to particula...

Topics

Acetolactate Synthase
Amino Acids
Drug Resistance
Enzyme Activation
Enzyme Inhibitors
Herbicides
Imidazoles
Models, Molecular
Molecular Structure
Mutation
Sulfonylurea Compounds
Yeasts

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