Article
The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2006
Rosa Araceli, Cuesta Manuel J, Fatjó-Vilas Mar, Peralta Víctor, Zarzuela Amalia, Fañanás Lourdes
Abstract excerpt
Schizophrenia (SZ) is a prevalent and severe mental disorder. One of the most favored hypotheses for the etiology of SZ is the neurodevelopmental hypothesis. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin growth factor family, promotes the development, regeneration, and survival of neurons and has been linked to the neuropathology of SZ. The present study tested, in a sample of 94 nuclear...
Topics
- Adult
- Alleles
- Amino Acid Substitution
- Analysis of Variance
- Brain-Derived Neurotrophic Factor
- Family Health
- Female
- Gene Frequency
- Genotype
- Humans
- Linkage Disequilibrium
- Male