Article
Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.
Biological psychiatry - 1 Apr 2007
Gratacòs Mònica, González Juan R, Mercader Josep M, de Cid Rafael, Urretavizcaya Mikel, Estivill Xavier
Abstract excerpt
BACKGROUND: There is an increasing recognition that the pathophysiology of mental disorders could be the result of deregulation of synaptic plasticity with alterations of neurotrophins. The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been extensively studied through linkage and association approaches in several psychiatric disorders....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.