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Montelukast suppresses the development of irritable bowel syndrome phenotype possibly through modulating NF-κB signaling in an experimental model.

Inflammopharmacology - 1 Feb 2022

Khodabakhsh Pariya, Khoie Nilgoon, Dehpour Ahmad-Reza, Abdollahi Alireza, Ghazi-Khansari Mahmoud, Shafaroodi Hamed

Abstract excerpt

Irritable bowel syndrome (IBS) is a functional gut disorder with multi-factorial pathophysiology that causes recurring pain or discomfort in the abdomen, as well as altered bowel habits. Montelukast, a well-known cysteinyl leukotriene receptor 1 (CysLT1R) antagonist, is widely used for the anti-inflammatory management of asthma. The present study aimed to evaluate the effects of pharmacological inhibition of...

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PMID: 35013876
DOI: 10.1007/s10787-021-00907-7

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