Article
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.
The Journal of allergy and clinical immunology - 1 Apr 2006
Kawaguchi Mio, Takahashi Daisuke, Hizawa Nobuyuki, Suzuki Shintaro, Matsukura Satoshi, Kokubu Fumio, Maeda Yukiko, Fukui Yoshinobu, Konno Satoshi, Huang Shau-Ku, Nishimura Masaharu, Adachi Mitsuru
Abstract excerpt
BACKGROUND: IL-17F is a recently discovered cytokine that plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma. OBJECTIVE: To investigate the role of IL-17F in asthma...
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