Article
MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Pongstaporn Wanida, Pakakasama Samart, Chaksangchaichote Panee, Pongtheerat Tanett, Hongeng Suradej, Permitr Songsak
Abstract excerpt
BACKGROUND: MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. MATERIALS AND METHODS: To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and...
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