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Article

Mutations in p53 cDNA sequence introduced by retroviral vector.

Biochemical and biophysical research communications - 10 Feb 2006

Su Su, Watanabe Atsushi, Yamamoto Motoko, Nakajima Eiitsu, Miyake Koichi, Shimada Takashi

Abstract excerpt

The high mutation rates of retroviruses are a potential problem with retroviral vectors. We studied the mutation rates and spectra of p53 sequences transduced with a retroviral vector in a cancer gene therapy model. When p53-deficient H358 non-small cell lung cancer cells were treated with a retroviral vector carrying normal p53 cDNA, most of transduced cells were killed by apoptosis. However, a small number of...

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Identifiers

PMID: 16380088
DOI: 10.1016/j.bbrc.2005.12.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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