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Article

Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.

Biochemical and biophysical research communications - 17 Feb 2006

Tanaka Motofumi, Nagano-Fujii Motoko, Deng Lin, Ishido Satoshi, Sada Kiyonao, Hotta Hak

Abstract excerpt

The N-terminal domain of NS3 of hepatitis C virus (HCV) possesses serine protease activity, which is essential for virus replication. This portion is also implicated in malignant transformation of hepatocytes. We previously demonstrated that an N-terminal portion of NS3 formed a complex with the tumor suppressor p53 and suppressed actinomycin D-induced apoptosis. We report here that single-point mutations of NS3...

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PMID: 16380082
DOI: 10.1016/j.bbrc.2005.12.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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