Article
Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.
PloS one - 1 Jan 2014
Ratnoglik Suratno Lulut, Jiang Da-Peng, Aoki Chie, Sudarmono Pratiwi, Shoji Ikuo, Deng Lin, Hotta Hak
Abstract excerpt
Effective therapeutic vaccines against virus infection must induce sufficient levels of cell-mediated immune responses against the target viral epitopes and also must avoid concomitant risk factors, such as potential carcinogenic properties. The nonstructural protein 3 (NS3) of hepatitis C virus...
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