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Article

Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.

Journal of virology - 1 Jul 2004

Thibeault Diane, Bousquet Christiane, Gingras Rock, Lagacé Lisette, Maurice Roger, White Peter W, Lamarre Daniel

Abstract excerpt

Hepatitis C virus (HCV) displays a high degree of genetic variability. Six genotypes and more than 50 subtypes have been identified to date. In this report, kinetic profiles were determined for NS3 proteases of genotypes 1a, 1b, 2ac, 2b, and 3a, revealing no major differences in activity. In vitro sensitivity studies with BILN 2061 showed a decrease in affinity for proteases of genotypes 2 and 3 (K(i), 80 to 90...

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Source

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Identifiers

PMID: 15220408
DOI: 10.1128/JVI.78.14.7352-7359.2004
PMCID: PMC434094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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